Hemostatic Abnormalities in Dementia: A Systematic Review and Meta-Analysis
| Autor: | Rita Carolina Figueiredo Duarte, Maria das Graças Carvalho, Walter Batista Cicarini, Marcos Vinícius Ferreira Silva, Karina Braga Gomes Borges, Paulo Caramelli, Cristina de Mello Gomide Loures, Leonardo Cruz de Souza |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Homocysteine 030204 cardiovascular system & hematology Hemostatics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Von Willebrand factor Alzheimer Disease Internal medicine medicine Dementia Humans Cognitive decline Vascular dementia biology business.industry Hematology medicine.disease Confidence interval chemistry Strictly standardized mean difference Meta-analysis biology.protein Cardiology and Cardiovascular Medicine business 030215 immunology |
| Zdroj: | Seminars in thrombosis and hemostasis. 45(5) |
| ISSN: | 1098-9064 |
| Popis: | Alzheimer's disease (AD) is considered the most frequent cause of dementia. It is known that vascular risk factors play an important role in the development and progression of this condition. Alterations in vascular walls represent documented findings in patients with AD and other dementias affecting elderly people. The authors performed a systematic review and meta-analysis, aiming to synthesize observational studies that evaluated how the hemostatic system may contribute to cognitive decline in the elderly, using papers published until April 2018 and as indexed in Medline (PubMed), Scopus, Web of Science, ScienceDirect, Lilacs, Cinahl, PsycINFO, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. Among 5,278 studies identified, 32 were included in the final synthesis, and these included 485 patients with mild cognitive impairment, 568 with vascular dementia (VD), 1,781 with AD, and 2,855 participants without dementia. AD patients had increased plasma von Willebrand factor (VWF) (standardized mean difference [SMD]: 2.53; 95% confidence interval [CI]: 0.10–4.95), D-dimer (SMD: 0.50; 95% CI: 0.35–0.66), plasminogen activator inhibitor-1 (SMD: 3.34; 95% CI: 1.01–5.67), thrombomodulin (SMD: 1.08; 95% CI: 0.53–1.62), and homocysteine levels (SMD: 0.65; 95% CI: 0.15–1.15). In contrast, the VD group showed increased fibrinogen levels (SMD: 0.77; 95% CI: 0.13–1.41), activated factor VII (SMD: 0.36; 95% CI: 0.05–0.67), factor VIII (SMD: 0.57; 95% CI: 0.22–0.91), VWF (SMD: 2.34; 95% CI: 0.38–4.29), D-dimer (SMD: 1.14; 95% CI: 0.51–1.78), and homocysteine (SMD: 2.17; 95% CI: 1.67–2.68). AD showed an elevation in some markers of endothelial dysfunction, whereas VD presented mostly an involvement of coagulation cascade components. |
| Databáze: | OpenAIRE |
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