The interval from surgery to chemotherapy in the treatment of advanced epithelial ovarian carcinoma
| Autor: | Jonathan H Shanks, Andrew R Clamp, Henry C Kitchener, Sin C Lau, Saifee Mullamitha, Gregory Wilson, Richard D Clayton, Richard J Slade, Gordon C Jayson, Daniela Dornelles Rosa, Jurjees Hasan, Ric Swindell, Louise M Byrd, Rhona J McVey, Nhuan C Ton |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Prognostic variable Neoplasm Residual Time Factors Multivariate analysis Ovariectomy medicine.medical_treatment Antineoplastic Agents Platinum Compounds Hysterectomy Carboplatin Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans Medicine Fallopian Tubes Survival analysis Aged Neoplasm Staging Cancer staging Aged 80 and over Ovarian Neoplasms Stage III Ovarian Cancer Chemotherapy Performance status business.industry Carcinoma General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Surgery Treatment Outcome Chemotherapy Adjuvant CA-125 Antigen Female business Ovarian cancer Omentum Follow-Up Studies |
| Zdroj: | European Journal of Surgical Oncology (EJSO). 32:588-591 |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2006.02.013 |
| Popis: | Background To study the effect of the interval between surgery and the start of chemotherapy in the treatment of patients with advanced ovarian cancer. Methods We stratified patients according to the start of platinum-based chemotherapy in group 1 (within 4 weeks from surgery), group 2 (between 4 and 8 weeks) and group 3 (between 8 and 12 weeks). Results Three hundred and ninty-four stage III ovarian cancer patients were analysed. In the multivariate analysis there were no differences in survival according to the interval between surgery and chemotherapy among the three groups. The independent prognostic variables were type of procedure ( p =0.014), performance status ( p =0.040) and post-chemotherapy CA-125 ( p Conclusions The interval between surgery and chemotherapy does not affect outcome. |
| Databáze: | OpenAIRE |
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