Comprehensive preterm breast milk metabotype associated with optimal infant early growth pattern
| Autor: | Marie-Cécile Alexandre-Gouabau, Sophie Cholet, Agnès David-Sochard, Dominique Darmaun, Thomas Moyon, Yann Guitton, Clair-Yves Boquien, Anne-Lise Royer, François Fenaille, Hélène Billard, Jean-Christophe Rozé |
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| Přispěvatelé: | Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Service de Pharmacologie et d'Immunoanalyse (SPI), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut National de la Recherche Agronomique (INRA), Laboratoire d'étude des Résidus et Contaminants dans les Aliments (LABERCA), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), European Milk Bank Association [Milan, Italie] (EMBA), Alexandre-Gouabau, Marie Cécile, Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Médecine humaine et pathologie Physiology lcsh:TX341-641 Breast milk preterm infant 03 medical and health sciences chemistry.chemical_compound lipidome growth trajectory breast milk metabolome Metabolome Food and Nutrition Choline Medicine glycome 2. Zero hunger 030109 nutrition & dietetics Nutrition and Dietetics business.industry Confounding food and beverages Lipidome 3. Good health free amino acid 030104 developmental biology chemistry Alimentation et Nutrition Cohort Gestation Population study Human health and pathology business lcsh:Nutrition. Foods and food supply [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Food Science |
| Zdroj: | Nutrients Nutrients, MDPI, 2019, 11 (3), pp.1-26. ⟨10.3390/nu11030528⟩ Nutrients, Vol 11, Iss 3, p 528 (2019) Nutrients 3 (11), 1-26. (2019) Volume 11 Issue 3 Nutrients, 2019, 11 (3), pp.1-26. ⟨10.3390/nu11030528⟩ |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11030528⟩ |
| Popis: | Early nutrition impacts preterm infant early growth rate and brain development but can have long lasting effects as well. Although human milk is the gold standard for feeding new born full-term and preterm infants, little is known about the effects of its bioactive compounds on breastfed preterm infants&rsquo growth outcomes. This study aims to determine whether breast milk metabolome, glycome, lipidome, and free-amino acids profiles analyzed by liquid chromatography-mass spectrometry had any impact on the early growth pattern of preterm infants. The study population consisted of the top tercile-Z score change in their weight between birth and hospital discharge (&ldquo faster grow&rdquo n = 11) and lowest tercile (&ldquo slower grow&rdquo n = 15) from a cohort of 138 premature infants (27&ndash 34 weeks gestation). This holistic approach combined with stringent clustering or classification statistical methods aims to discriminate groups of milks phenotype and identify specific metabolites associated with early growth of preterm infants. Their predictive reliability as biomarkers of infant growth was assessed using multiple linear regression and taking into account confounding clinical factors. Breast-milk associated with fast growth contained more branched-chain and insulino-trophic amino acid, lacto-N-fucopentaose, choline, and hydroxybutyrate, pointing to the critical role of energy utilization, protein synthesis, oxidative status, and gut epithelial cell maturity in prematurity. |
| Databáze: | OpenAIRE |
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