Extrapancreatic action of sulphonylureas: effect of gliquidone on insulin and glucagon binding to rat liver plasma membranes
| Autor: | M. Haslbeck, Hellmut Mehnert, W. Bachmann, I. Böttger |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
endocrine system medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Glucagon binding Biochemistry Glucagon Internal medicine medicine Animals Insulin Diminution Binding Sites Chemistry Cell Membrane General Medicine Rats Sulfonylurea Compounds Membrane Endocrinology Liver Second generation sulphonylurea Rat liver Gliquidone medicine.drug |
| Zdroj: | European Journal of Clinical Investigation. 9:411-415 |
| ISSN: | 1365-2362 0014-2972 |
| DOI: | 10.1111/j.1365-2362.1979.tb00905.x |
| Popis: | Gliquidone (a second generation sulphonylurea) was administered orally to normal rats 1 h before killing. Gliquidone treatment led to a decrease in plasma glucose, an increase in insulin and a diminution in glucagon concentration. Insulin binding to liver plasma membranes was enhanced by 40% in comparison with controls, whereas glucagon binding was slightly diminished. These findings indicate a greater sensitivity of liver cells to insulin during sulphonylurea treatment and support the view that sulphonylureas potentiate insulin action on the liver. |
| Databáze: | OpenAIRE |
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