Circadian Variation in the Onset of Placental Abruption
| Autor: | Hiroshi Sameshima, Masanao Ohhashi, Seishi Furukawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Abdominal pain medicine.medical_specialty Time Factors Article Subject Perinatal Death 030204 cardiovascular system & hematology lcsh:Gynecology and obstetrics 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors medicine Humans Vaginal bleeding Circadian rhythm Abruptio Placentae lcsh:RG1-991 Retrospective Studies Analysis of Variance 030219 obstetrics & reproductive medicine Placental abruption Obstetrics business.industry Incidence (epidemiology) Incidence Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Retrospective cohort study Odds ratio medicine.disease Abdominal Pain Circadian Rhythm Clinical Study Female Uterine Hemorrhage medicine.symptom business |
| Zdroj: | Journal of Pregnancy, Vol 2017 (2017) Journal of Pregnancy |
| ISSN: | 2090-2735 2090-2727 |
| Popis: | Objective. To determine circadian variation in the onset of placental abruption.Methods. A retrospective study involving 115 placental abruptions, divided into four subgroups based on initial symptoms comprising abdominal pain, vaginal bleeding, both abdominal pain and bleeding, or other symptoms. The time of the initial symptom was considered the disease onset. We analyzed the frequency of disease onset and adverse perinatal outcome including perinatal death relative to the daily four 6-hour intervals.Results. Abdominal pain displayed significant circadian variation regarding the period of onset with higher levels from 0:00 AM to 6:00 AM (65%) compared with 0:00 PM to 6:00 PM (24%,p<0.01). Vaginal bleeding did not display significant circadian variation (p=0.45). Adverse perinatal outcome showed significant circadian variation with a higher occurrence of perinatal death from 0:00 AM to 6:00 AM (35%) compared with 0:00 PM to 6:00 PM (0%,p<0.01). After adjustment using variables of abdominal pain and time period, both variables significantly affected perinatal death (odds ratio: 13.0 and 2.2, resp.). The risk of adverse perinatal outcome increased significantly when abdominal pain occurred, except for the period 0:00 PM to 6:00 PM (OR, 9.5).Conclusion. Placental abruption beginning with abdominal pain has circadian variation. |
| Databáze: | OpenAIRE |
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