Huntington's disease and steroid hormone receptors
| Autor: | Linda Bebarova, Marcela Bezdickova, Radka Molikova, Ondrej David |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Estrogen receptor Nerve Tissue Proteins Disease Biology Bioinformatics General Biochemistry Genetics and Molecular Biology Cell Line Steroid Huntington's disease Internal medicine medicine Humans Receptor Brain Sex hormone receptor medicine.disease Androgen Immunohistochemistry Steroid hormone Huntington Disease Endocrinology Receptors Estrogen |
| Zdroj: | Biomedical Papers. 151:53-57 |
| ISSN: | 1804-7521 1213-8118 |
| DOI: | 10.5507/bp.2007.009 |
| Popis: | Background: Steroid hormone receptors constitute a special group of receptors having a wide range of effi ciency and distribution in the body. Androgen and estrogen receptors, and their expression in the body, are linked with attributes such as reproduction control and sexual behaviour, but their relation with behavioural models, perception, memory and stress remain unclear to date. Purpose: In this project we aim to focus on monitoring the expressive infl uence of steroid hormone receptors on embryonic tissues and subsequently, expand our study to include the expression on adult tissues such as the CNS and to monitor the developmental aspects and relations pertaining to neurodegenerative disorders, such as Huntington’s disease. Material and Methods: We shall rely on immuno-histochemistry, immuno-fl uorescence and RT-PCR methods for detecting steroid hormone receptors and Huntingtin-associated protein 1 in the embryonic and adult tissue. Conclusion: Mapping the expression of steroid receptors during development represents an essential step in the quest for further studies and monitoring of the expression in adult tissues. |
| Databáze: | OpenAIRE |
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