Fully resorbable poly-4-hydroxybutyrate (P4HB) mesh for soft tissue repair and reconstruction: A scoping review
| Autor: | Corey R. Deeken, David C. Chen, Manuel Lopez-Cano, David P. Martin, Amit Badhwar |
|---|---|
| Přispěvatelé: | Institut Català de la Salut, [Deeken CR] Covalent Bio, LLC, St. Louis, MO, United States. [Chen DC] Section of Minimally Invasive Surgery, David Geffen School of Medicine at University of California, Los Angeles, Santa Monica, CA, United States. [Lopez-Cano M] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Martin DP, Badhwar A] Becton, Dickinson and Company, Warwick, RI, United States, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Pathological Conditions
Signs and Symptoms::Pathological Conditions Anatomical::Hernia [DISEASES] Enginyeria de teixits afecciones patológicas signos y síntomas::afecciones patológicas anatómicas::hernia [ENFERMEDADES] Surgery Hèrnia - Cirurgia - Complicacions Otros calificadores::Otros calificadores::/cirugía [Otros calificadores] equipos y suministros::equipo quirúrgico::mallas quirúrgicas [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Equipment and Supplies::Surgical Equipment::Surgical Mesh [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Other subheadings::Other subheadings::/surgery [Other subheadings] |
| Zdroj: | Scientia |
| Popis: | Hernia recurrence; Resorbable; Surgical site infection Recurrencia de hernia; Reabsorbible; Infección del sitio quirúrgico Recurrència d'hèrnia; Reabsorbible; Infecció del lloc quirúrgic Background: Poly-4-hydroxybutyrate (P4HB) is a fully resorbable, biologically-produced polymer with a strength and flexibility comparable to permanent synthetic polymers. The objective was to identify/summarize all peer-reviewed publications involving P4HB mesh. Methods: A scoping review was conducted within PubMed and included articles published through October 2022. Results: A total of n = 79 studies were identified (n = 12 in vitro/bench; n = 14 preclinical; n = 6 commentaries; n = 50 clinical). Of the clinical studies, n = 40 reported results applicable to hernia and n = 10 to plastic/reconstructive surgery and involved patients of all Centers for Disease Control (CDC) wound classes and Ventral Hernia Working Group (VHWG) grades. Conclusion: P4HB mesh provides long-term hernia repair strength and exhibits promising clinical outcomes beyond its resorption period. Future studies should include randomized controlled trials comparing P4HB to other biomaterials, as well as optimal patient selection, operative technique, long-term outcomes, minimization of potential mesh-related complications, and potential contraindications/complications for P4HB in hernia/abdominal wall reconstruction. This project was sponsored by Becton, Dickinson and Company (BD) of Warwick, Rhode Island (USA). CD is the owner of Covalent Bio, LLC, which received consulting fees from BD for this project, as well as other, unrelated projects. DM and AB are employees of BD. DC and ML are consultants for BD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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