A d-norgestrel-releasing IUD
| Autor: | Johansson E.D.B., Tapani Luukkainen, Carl Gustaf Nilsson |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
medicine.medical_specialty media_common.quotation_subject Population Ovary Endometrium 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Endocrine system Levonorgestrel 030212 general & internal medicine education Ovulation Menstruation Disturbances Progesterone media_common education.field_of_study 030219 obstetrics & reproductive medicine Estradiol business.industry Norgestrel Intrauterine Devices Medicated Obstetrics and Gynecology Metrorrhagia Silastic 3. Good health medicine.anatomical_structure Endocrinology Reproductive Medicine Delayed-Action Preparations Silicone Elastomers Female medicine.symptom business Intrauterine Devices Hormone medicine.drug |
| Zdroj: | Contraception. 13:503-514 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/s0010-7824(76)80036-4 |
| Popis: | Steady release of d-norgestrel from an IUD was achieved with a plain Tatum-T-device, the carrier material being sleeves of silastic R . The device was tested in six healthy women, and plasma concentrations of d-norgestrel, estradiol and progesterone were determined for periods of 112–114 days. The values found corresponded to a daily release of 50 μg d-norgestrel. This amount was enough to suppress ovulation. The bleeding pattern was irregular, but the amount of bleeding was reduced. Biopsies showed endometrial hypofunction. The advantage of the intrauterine route of administration of d-norgestrel is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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