Isolation and Structural Characterization of Two New Furanoditerpenes from Pterodon emarginatus (Fabaceae)
| Autor: | Sérgio de Albuquerque, Wanderson Romão, Geralda de Fátima Lemes, Boniek G. Vaz, Gerlon de Almeida Ribeiro Oliveira, Maria Teresa Freitas Bara, Luciano M. Lião, Cristiana Gonçalez, Leandra A. R. de Oliveira |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Leishmania
Leishmania amazonensis Lysis Chromatography biology 010405 organic chemistry Chemistry Electrospray ionization General Chemistry Fabaceae biology.organism_classification 01 natural sciences High-performance liquid chromatography Fourier transform ion cyclotron resonance 0104 chemical sciences vouacapan 010404 medicinal & biomolecular chemistry furanoditerpenes Pterodon emarginatus Pterodon |
| Zdroj: | Journal of the Brazilian Chemical Society, Volume: 28, Issue: 10, Pages: 1911-1916, Published: OCT 2017 Journal of the Brazilian Chemical Society v.28 n.10 2017 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| Popis: | A furanoditerpene-enriched fraction was obtained from the fruits of Pterodon emarginatus and submitted to semipreparative high performance liquid chromatography (HPLC). Two new furanoditerpenes, 6α,19β-diacetoxy-7β,14β-dihydroxyvouacapan and 6α-acetoxy-7β,14β-dihydroxyvouacapan, in addition to the known compound methyl 6α-acetoxy-7β-hydroxyvouacapan-17β-oate were obtained. Compound structures were determined by 1D and 2D nuclear magnetic resonance (NMR) experiments and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS). The major compound methyl 6α-acetoxy-7β-hydroxyvouacapan-17β-oate was evaluated against promastigote forms of Leishmania amazonensis and L. braziliensis, presenting the concentration which causes lysis on 50% of parasites IC50 < 30 µg mL-1. |
| Databáze: | OpenAIRE |
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