Reevaluating the Microbial Infection Link to Alzheimer’s Disease
| Autor: | Ehud Gazit, Zohar A. Arnon, Lee Schnaider |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Disease Infections 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Humans Medicine Dementia Aged Aged 80 and over business.industry General Neuroscience Neurodegeneration Herpesviridae Infections General Medicine medicine.disease Gingivitis Psychiatry and Mental health Clinical Psychology 030104 developmental biology Molecular mechanism Causal link Geriatrics and Gerontology Amyloid cascade business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 73:59-62 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-190765 |
| Popis: | Alzheimer's disease (AD) is the most common cause of dementia. Despite substantial investment in research, there are no current effective treatments to prevent or delay the onset and development of AD and the exact molecular mechanism of AD pathogenesis is still not fully understood. Researchers have long suspected that microbial infections may play a role in AD; however, this hypothesis has been greatly overlooked for decades, only recently gaining a traction and recognition within the broad scientific community due to new overwhelming evidence on the association of various pathogenic microbes and AD. Here, we provide our perspective on the significance of these findings, which shed light on the interplay between molecular self-assembly, neurodegeneration, and antimicrobial peptides, as well as propose an amendment to the amyloid cascade hypothesis. It is important to note that this association does not yet prove a causal link, but these reports warrant a thorough investigation into the microbial infection-AD hypothesis which might in turn deliver the elusive therapeutic target the scientific community has been so desperately searching for. |
| Databáze: | OpenAIRE |
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