RADIOTHERAPY GENETIC ALGORITHM PARETO-MULTIOBJECTIVE OPTIMIZATION OF BIOLOGICAL EFFECTIVE DOSE AND CLONOGENS MODELS FOR BREAST TUMOR IMPROVED TREATMENT

Autor: Francisco Casesnoves
Rok vydání: 2023
Předmět:
Pareto-Multiobjective Optimization (PMO)
Mathematical Methods (MM)
Biological Models (BM)
Radiation Therapy (RT)
Initial Tumor Clonogenes Number Population ( N0 )
Effective Tumor Population Clonogenes Number ( NEff )
Linear Quadratic Model (LQM)
Integral Equation (IE)
Tumor Control Probability (TCP)
Biological Effective model (BED)
Tumor Control Cumulative Probability (TCCP)
Radiation Photon-Dose (RPD)
Nonlinear Optimization
Radiotherapy Treatment Planning Optimization (TPO)
Source-Surface Distance (SSD)
Software Engineering Methods
Radiation Photon-Dose
Attenuation Exponential Factor (AEF)
Nonlinear Optimization
Radiotherapy Wedge Filter (WF)
Anisotropic Analytic Model (AAA)
Fluence Factor (FF)
Omega Factor (OF)
Treatment Planning Optimization (TPO)
Breast Tumor (BT)
Artificial Intelligence (AI)
DOI: 10.5281/zenodo.7499351
Popis: BED model (Biological Effective Dose) for Hyperfractionation TPO was optimized with Pareto-Multiobjective Genetic Algorithms (GA) software. Secondly, the NEffective(Effective Tumor Population Clonogens Number) model optimization for breast cancer clonogens parameters determination in TPO (Treatment Planning Optimization) is carried out with 3D Graphical and Interior Optimization methods. BED model (Biological Effective Dose) for Hyperfractionation TPO was optimized with Pareto-Multiobjective GA software. Results comprise imaging process series and numerical values of NEffectivemodel for breast cancer parameters. Additional results demonstrate Pareto-Multiobjective GA BED model both with Pareto-Optimal Front graphics, charts and numerical dose fractionation datasets. For all these findings, supplementary new recent applications with 3D Isodoses TPO with AAA (Anisotropic Analytic Algorithm) model wedge filters dose delivery is shown. Modern RT treatment breast cancer, and tumors in general for Fractionation-dose protocols are explained.
Databáze: OpenAIRE