Regulators of commensal and pathogenic life‐styles of an opportunistic fungus— Candida albicans

Autor: Sophie Bachellier-Bassi, Lasse van Wijlick, Marie-Elisabeth Bougnoux, Christophe d'Enfert, Laxmi Shanker Rai
Přispěvatelé: Biologie et Pathogénicité fongiques - Fungal Biology and Pathogenicity (BPF), Institut Pasteur [Paris] (IP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris], Assistance Publique - Hôpitaux de Paris, LSR is the recipient of a post‐doctoral fellowship of the Fondation pour la Recherche Médicale (FRM, DBF20160635719) and LvW of the Agence Nationale de la Recherche (CANDIHUB, ANR‐14‐CE‐0018). Work in the laboratory of CdE has been supported by grants from the Agence Nationale de la Recherche (ERA‐Net Infect‐ERA, FUNCOMPATH, ANR‐14‐IFEC‐0004) and the French Government's Investissement d'Avenir program (Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases, ANR‐10‐LABX‐62‐IBEID)., ERA-Net Infect-ERA, FUNCOMPATHFondation pour la Recherche MedicaleDBF20160635719, ANR-14-CE14-0018,CANDIHUB,Réponse au stress et virulence chez les champignons pathogènes de l'homme : une approche comparative systémique des réseaux de régulation chez les espèces du genre Candida(2014), ANR-14-IFEC-0004,FunComPath,From fungal commensalism to pathogenicity:dissection of the colonization-to-infection shift of Candida albicans(2014), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Rok vydání: 2021
Předmět:
Zdroj: Yeast
Yeast, 2021, 38 (4), pp.243-250. ⟨10.1002/yea.3550⟩
Yeast, Wiley, 2021, 38 (4), pp.243-250. ⟨10.1002/yea.3550⟩
ISSN: 1097-0061
0749-503X
Popis: International audience; The yeast Candida albicans is primarily a commensal of humans that colonizes the mucosal surfaces of the gastrointestinal and genital tracts. Yet, C. albicans can under certain circumstances undergo a shift from commensalism to pathogenicity. This transition is governed by fungal factors such as morphological transitions, environmental cues for instance relationships with gut microbiota and the host immune system. C. albicans utilizes distinct sets of regulatory programs to colonize or infect its host and to evade the host defense systems. Moreover, an orchestrated iron acquisition mechanism operates to adapt to specific niches with variable iron availability. Studies on regulatory networks and morphogenesis of these two distinct modes of C. albicans growth, suggest that both yeast and hyphal forms exist in both growth patterns and the regulatory circuits are inter‐connected. Here, we summarize current knowledge about C. albicans commensal‐to‐pathogen shift, its regulatory elements and their contribution to human disease.
Databáze: OpenAIRE
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