Localization and upregulation of survivin in cancer health disparities: a clinical perspective
| Autor: | David Turay, Carlos J. Diaz Osterman, Heather R. Ferguson Bennit, Malyn May Asuncion Valenzuela, Arjun Ashok, Ron B. Moyron, Nathan R. Wall, Grace E. Esebanmen, Salma Khan |
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| Rok vydání: | 2015 |
| Předmět: |
Review
exosomes survivin Bioinformatics Immune system Rheumatology Downregulation and upregulation Prostate Survivin medicine cancer Immunology and Allergy Pharmacology (medical) Tumor microenvironment business.industry Gastroenterology Cancer medicine.disease Microvesicles 3. Good health medicine.anatomical_structure Oncology Apoptosis Cancer research business health disparity |
| Zdroj: | Biologics : Targets & Therapy |
| ISSN: | 1177-5491 |
| DOI: | 10.2147/btt.s83864 |
| Popis: | Survivin is one of the most important members of the inhibitors of apoptosis protein family, as it is expressed in most human cancers but is absent in normal, differentiated tissues. Lending to its importance, survivin has proven associations with apoptosis and cell cycle control, and has more recently been shown to modulate the tumor microenvironment and immune evasion as a result of its extracellular localization. Upregulation of survivin has been found in many cancers including breast, prostate, pancreatic, and hematological malignancies, and it may prove to be associated with the advanced presentation, poorer prognosis, and lower survival rates observed in ethnically diverse populations. |
| Databáze: | OpenAIRE |
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