Cytokine dependent hematopoietic cell linker (CLNK) is highly elevated in blood transfusion dependent beta-thalassemia major patients
| Autor: | Shatha Rouf Moustafa, Michael Maes, Hawraa Hussein Al-Mayali, Hussein Kadhem Al-Hakeim |
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| Rok vydání: | 2021 |
| Předmět: |
Iron Overload
Blood transfusion medicine.medical_treatment Thalassemia Clinical Biochemistry Inflammation 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Immune system medicine Humans Blood Transfusion Child Receptor biology business.industry beta-Thalassemia Biochemistry (medical) Hematopoietic Stem Cell Transplantation Hematology medicine.disease Ferritin Cytokine Child Preschool Immunology biology.protein Cytokines medicine.symptom Signal transduction business 030215 immunology |
| Zdroj: | Transfusion Clinique et Biologique. 28:194-198 |
| ISSN: | 1246-7820 |
| DOI: | 10.1016/j.tracli.2021.01.003 |
| Popis: | BACKGROUND Transfusion-dependent β-thalassemia (TDT) is a severe form of thalassemia caused by mutations in the β-globin gene, resulting in partial or complete deficiency of β-globin chains. This deficiency results in oxidative stress, dyserythropoiesis, and chronic anemia. Cytokine-dependent hematopoietic cell linker (CLNK) belongs to adaptor proteins that have the capacity to interact with multiple signalling proteins and function in the organisation of the molecular components required for signal transduction. OBJECTIVES This is the first study which measured serum CLNK in TDT patients and examines the correlation between CLNK and iron overload biomarkers. PATIENTS AND METHODS Sixty children with TDT and 30 normal children (aged 3-12 years old) participated in the present study. The patients were on blood transfusion as a part of their treatment regimen. Serum C-reactive protein was negative in all samples. RESULTS The results showed significantly higher (P |
| Databáze: | OpenAIRE |
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