Neutrophil anti-neutrophil cytoplasmic autoantibody proteins: bactericidal increasing protein, lactoferrin, cathepsin, and elastase as serological markers of inflammatory bowel and other diseases
| Autor: | Evaggelos C. Karvounis, Kallirroi Kyriakidi, Epameinondas V Tsianos, Vasileios E. Tsianos, Konstantinos Katsanos, Dimitrios K. Christodoulou |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
cathepsin G
Review Article Cathepsin G Inflammatory bowel disease Pathogenesis 03 medical and health sciences chemistry.chemical_compound anti-neutrophil cytoplasmic autoantibody 0302 clinical medicine Medicine bactericidal increasing protein elastase biology business.industry Lactoferrin Elastase Gastroenterology Autoantibody medicine.disease Ulcerative colitis digestive system diseases lactoferrin chemistry 030220 oncology & carcinogenesis Immunology biology.protein Biomarker (medicine) 030211 gastroenterology & hepatology business |
| Zdroj: | Annals of Gastroenterology : Quarterly Publication of the Hellenic Society of Gastroenterology |
| ISSN: | 1792-7463 1108-7471 |
| Popis: | Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract comprising Crohn's disease and ulcerative colitis. Although the pathogenesis of the disease is not clearly defined yet, environmental, genetic and other factors contribute to the onset of the disease. Apart from the clinical and histopathological findings, several serological biomarkers are also employed to detect IBD. One of the most thoroughly studied biomarker is anti-neutrophil cytoplasmic autoantibody (ANCA). We herein provide an overview of the current knowledge on the use of ANCA and certain ANCA proteins, such as bactericidal increasing protein, lactoferrin, cathepsin G and elastase, as serological markers for IBD and other diseases. |
| Databáze: | OpenAIRE |
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