Associations between nasal torquetenovirus load and spirometric indices in children with asthma
| Autor: | Fabrizio Maggi, Mauro Pistello, Vincenzo Ragazzo, Elisabetta Andreoli, Claudia Fornai, Pierantonio Macchia, Mauro Bendinelli, Emanuela De Marco, Attilio Boner, Massimo Pifferi, Maria Linda Vatteroni, Letizia Lanini |
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| Rok vydání: | 2004 |
| Předmět: |
Spirometry
Male medicine.medical_specialty Vital capacity Adolescent Population Vital Capacity Nose Gastroenterology FEV1/FVC ratio children Internal medicine Forced Expiratory Volume otorhinolaryngologic diseases medicine Immunology and Allergy Humans education Child Lung Asthma Torque teno virus education.field_of_study Eosinophil cationic protein medicine.diagnostic_test business.industry Forced Expiratory Flow Rates respiratory system Viral Load medicine.disease DNA Virus Infections respiratory tract diseases Respiratory Function Tests asthma torquetenovirus spirometric indices Infectious Diseases Immunology DNA Viral Sputum Female medicine.symptom business Viral load |
| Zdroj: | The Journal of infectious diseases. 192(7) |
| ISSN: | 0022-1899 |
| Popis: | Fifty-nine children with well-controlled, mild to moderate persistent asthma were studied for the presence and load of torquetenovirus (TTV) in nasal fluid. Rates of TTV positivity and mean nasal TTV loads were not dissimilar to those observed in the general population and in a group of 30 age- and residence-matched healthy control children without a history of asthmatic disease. However, in the children with asthma, 3 important indices of lung function--forced expiratory flow (FEF) in which 25% and 75% of forced vital capacity (FVC) is expired (FEF(25%-75%)), forced expiratory volume in 1 s/FVC, and FEF(25%-75%)/FVC--showed an inverse correlation with nasal TTV load. Furthermore, signs of reduced airflow were more frequent in the children with asthma who had high nasal TTV loads (> or =6 log(10) DNA copies/mL of nasal fluid) than they were in those who had low nasal TTV loads ( |
| Databáze: | OpenAIRE |
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