Brain-wide reconstruction of inhibitory circuits after traumatic brain injury
| Autor: | Jan C. Frankowski, Alexa Tierno, Shreya Pavani, Quincy Cao, David C. Lyon, Robert F. Hunt |
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| Rok vydání: | 2021 |
| Předmět: |
Traumatic
Neurons Brain Mapping Multidisciplinary Physical Injury - Accidents and Adverse Effects 1.1 Normal biological development and functioning Neurosciences General Physics and Astronomy Brain General Chemistry Traumatic Brain Injury (TBI) General Biochemistry Genetics and Molecular Biology Brain Disorders Mice Underpinning research Interneurons Brain Injuries Neurological Brain Injuries Traumatic Animals Traumatic Head and Spine Injury |
| Zdroj: | Nature communications, vol 13, iss 1 |
| ISSN: | 2041-1723 |
| Popis: | Despite the fundamental importance of understanding the brain’s wiring diagram, our knowledge of how neuronal connectivity is rewired by traumatic brain injury remains remarkably incomplete. Here we use cellular resolution whole-brain imaging to generate brain-wide maps of the input to inhibitory neurons in a mouse model of traumatic brain injury. We find that somatostatin interneurons are converted into hyperconnected hubs in multiple brain regions, with rich local network connections but diminished long-range inputs, even at areas not directly damaged. The loss of long-range input does not correlate with cell loss in distant brain regions. Interneurons transplanted into the injury site receive orthotopic local and long-range input, suggesting the machinery for establishing distant connections remains intact even after a severe injury. Our results uncover a potential strategy to sustain and optimize inhibition after traumatic brain injury that involves spatial reorganization of the direct inputs to inhibitory neurons across the brain. |
| Databáze: | OpenAIRE |
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