The effects of dehydroepiandrosterone (DHEA) supplementation on body composition and blood pressure: A meta-analysis of randomized clinical trials
| Autor: | James C Price, Yanfei He, Heitor O. Santos, Brijesh Sathian, Furong Wang, Jianjun Diao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry Dehydroepiandrosterone Blood Pressure 030209 endocrinology & metabolism Biochemistry Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine Endocrinology Randomized controlled trial law Internal medicine medicine Humans Molecular Biology Randomized Controlled Trials as Topic Pharmacology business.industry Organic Chemistry Anthropometry medicine.disease Obesity Blood pressure 030220 oncology & carcinogenesis Meta-analysis Dietary Supplements Body Composition Lean body mass business Body mass index |
| Zdroj: | Steroids. 163:108710 |
| ISSN: | 0039-128X |
| Popis: | Dehydroepiandrosterone (DHEA) supplementation has been anecdotally considered as a tool to improve body composition and health status. We aimed to verify the impact of DHEA supplementation on traditional measurements of body composition and blood pressure (BP) due to their clinical applicability. A meta-analysis of randomized clinical trials was conducted based on the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Regarding anthropometric characteristics, DHEA supplementation did not change body weight (weighted mean difference (WMD): -0.16 kg, 95% CI: -1.02 to 0.70, p = 0.72) or body mass index (WMD: -0.18 kg/m2, 95% CI: -0.48 to 0.12, p = 0.24), but increased lean body mass (WMD: 0.45 kg, 95% CI: 0.15 to 0.75, p = 0.004) and decreased fat mass (WMD: -0.85 %, 95% CI: -1.18 to -0.51, p = 0.000), when compared to control groups. Neither systolic (WMD: 0.98 mm Hg, 95% CI: -2.31 to 4.29, p = 0.56) nor diastolic BP were significantly changed (WMD: -1.62 mm Hg, 95% CI: -5.49 to 2.24, p = 0.49). Our findings demonstrate that DHEA supplementation increased lean body mass and decreased fat mass, but debate persists when translating the results into clinical benefit. Lastly, DHEA supplementation had a neutral effect on BP. |
| Databáze: | OpenAIRE |
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