EV71 infection correlates with viral IgG preexisting at pharyngo-laryngeal mucosa in children
| Autor: | Huimin Yan, Jingchang Xue, Xiaoyi Xu, Jie Yu, Hu Yan, Yaoming Li |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Immunology Central nervous system medicine.disease_cause Antibodies Viral Laryngeal Mucosa Medical microbiology In vivo Virology medicine Enterovirus 71 Humans Antibodies Blocking biology business.industry Infant Viral Load biology.organism_classification Epithelium Enterovirus A Human medicine.anatomical_structure Child Preschool Immunoglobulin G biology.protein Molecular Medicine Enterovirus Pharynx RNA Viral Female Antibody business Research Article |
| Zdroj: | Virol Sin |
| ISSN: | 1995-820X |
| Popis: | Enterovirus 71 (EV71) infection causes severe central nervous system damage, particularly for children under the age of 5 years old, which remains a major public health burden worldwide. Clinical data released that children may be repeatedly infected by different members in enterovirus and get even worsen. Mucosa, especially epithelium of alimentary canal, was considered the primary site of EV71 infection. It has been elusive whether the preexsiting viral antibody in mucosa plays a role in EV71 infection. To answer this question, we respectively measured viral antibody response and EV71 RNA copy number of one hundred throat swab specimens from clinically confirmed EV71-infected children. The results released that low-level of mucosal IgG antibody against EV71 broadly existed in young population. More importantly, it further elucidated that the children with mucosal preexsiting EV71 IgG were prone to be infected, which suggested a former viral IgG mediated enhancement of viral infection in vivo. |
| Databáze: | OpenAIRE |
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