Hemiretinal Asymmetry in Peripapillary Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes
| Autor: | Xuejuan Jiang, Xiao Zhou, Brian J. Song, Brenda Ryuna Chang, Vivian LeTran, Zhongdi Chu, Brandon J. Wong, Grace M. Richter, Ruikang K. Wang, Jae C. Lee, Kendra L. Hong, Anna L. Urrea, Bruce Burkemper, Benjamin Y. Xu, Rohit Varma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Retinal Ganglion Cells
medicine.medical_specialty genetic structures Nerve fiber layer Glaucoma Logistic regression Article 03 medical and health sciences chemistry.chemical_compound Nerve Fibers 0302 clinical medicine Vessel density Optical coherence tomography Ophthalmology medicine Humans Intraocular Pressure 030304 developmental biology 0303 health sciences medicine.diagnostic_test business.industry Retinal Vessels Retinal Glaucoma suspect medicine.disease eye diseases Cross-Sectional Studies medicine.anatomical_structure chemistry 030221 ophthalmology & optometry sense organs Visual Fields business Glaucoma Open-Angle Tomography Optical Coherence Optic disc |
| Zdroj: | Am J Ophthalmol |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/j.ajo.2021.05.019 |
| Popis: | PURPOSE: To investigate hemiretinal asymmetry in radial peripapillary capillary vessel area density (VAD) of healthy, glaucoma suspect, and glaucoma eyes of varying severity and its diagnostic utility for glaucoma. DESIGN: Population-based, cross-sectional study. METHODS: 6×6-mm optic disc scans were collected on optical coherence tomography angiography (OCTA) to obtain VAD and on OCT to measure circumpapillary retinal nerve fiber layer (RNFL) thickness. Hemiretinal difference in VAD (hdVAD) was defined as the absolute difference between superior and inferior hemiretinal VAD. Age-adjusted multivariable linear regression of hdVAD on glaucoma severity was performed. Area under curves (AUCs) were calculated from predicted probabilities generated by multiple logistic regression of glaucoma severity on age-adjusted single and combined parameters. RESULTS: 1043 eyes of 1043 participants (587 healthy, 270 suspect, 67 mild, 54 moderate, 65 severe glaucoma) were included. After age adjustment, mean hdVAD was similar between healthy and suspect (P = 0.225), higher in mild versus suspect (P < 0.001), higher in moderate versus mild (P = 0.018), but lower in severe versus moderate (P = 0.001). AUCs of hdVAD were highest for discriminating mild (0.685) and moderate (0.681) glaucoma from healthy. Combining hdVAD and global RNFL (gRNFL) yielded the highest AUCs of all parameters for mild (0.817) and any POAG (0.859) and resulted in significantly better diagnostic accuracy than either hdVAD or gRNFL alone (P < 0.05 for all comparisons). CONCLUSIONS: hdVAD is higher in early glaucoma and may help with early detection when damage is focal, but its diagnostic ability appears less robust in advanced glaucoma when damage is diffuse. |
| Databáze: | OpenAIRE |
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