Microparticulated systems based on chitosan and poly(vinyl alcohol) with potential ophthalmic applications
| Autor: | Marcel Popa, Jean-François Chailan, Bernard Fache, Anca Niculina Cadinoiu, Catalina Anisoara Peptu |
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| Přispěvatelé: | 'Gheorghe Asachi' Technical University of Iaşi - Faculty of Chemical Engineering and Environmental Protection, Department of Natural Synthetic Polymers, Laboratoire Matériaux Polymères Interfaces Environnement Marin - EA 4323 (MAPIEM), Université de Toulon (UTLN) |
| Rok vydání: | 2015 |
| Předmět: |
Male
Vinyl alcohol Materials science Pharmaceutical Science Ionic bonding Bioengineering Muscarinic Agonists Chitosan Mice chemistry.chemical_compound Colloid and Surface Chemistry Materials Testing Polymer chemistry medicine Animals Humans Particle Size Physical and Theoretical Chemistry ComputingMilieux_MISCELLANEOUS Sustained release drug Organic Chemistry Pilocarpine technology industry and agriculture [CHIM.MATE]Chemical Sciences/Material chemistry Hydrogen-Ion Concentration Biocompatible material 3. Good health Drug Liberation [CHIM.POLY]Chemical Sciences/Polymers chemistry Chemical engineering Covalent bond Delayed-Action Preparations Polyvinyl Alcohol Emulsion Ophthalmic Solutions Swelling medicine.symptom |
| Zdroj: | Journal of Microencapsulation Journal of Microencapsulation, Taylor & Francis, 2015, 32 (4), pp.381-389. ⟨10.3109/02652048.2015.1035682⟩ |
| ISSN: | 1464-5246 0265-2048 |
| DOI: | 10.3109/02652048.2015.1035682 |
| Popis: | Spherical microparticles for encapsulation of drugs for the treatment of diseases, with a diameter ranging between 2 and 4 µm, were obtained by double crosslinking (ionic and covalent) of chitosan and poly(vinyl alcohol) blend in a water-in-oil emulsion. Microparticles characterisation was carried out in terms of structural, morphological and swelling properties in aqueous media. The presence of chitosan in particles composition confers them a pH-sensitive character. Toxicity and hemocompatibility tests prove the biocompatible character of microparticles. The pilocarpine loading capacity is high as well as the release efficiency which increases up to 72 and 82% after 6 h. The obtained results recommend the microparticles as sustained release drug carriers for the treatment of eye diseases. |
| Databáze: | OpenAIRE |
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