Incidence of Post-Transfusion Hepatitis before and after Screening for Hepatitis C Virus Antibody
| Autor: | Y Wang, Cho-Yu Chan, Shou-Dong Lee, Kwang-Juei Lo, Shiau-Ting Lai, Shinn-Jang Hwang, Mo-Ping Chow |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood transfusion Adolescent Hepatitis C virus medicine.medical_treatment Hepacivirus medicine.disease_cause Gastroenterology Serology Liver disease Internal medicine medicine Humans Mass Screening Hepatitis Antibodies Prospective Studies Aged Aged 80 and over Hepatitis business.industry Incidence Incidence (epidemiology) Transfusion Reaction Hematology General Medicine Hepatitis C Antibodies Middle Aged medicine.disease Hepatitis C Immunology Female Viral disease business Viral hepatitis |
| Zdroj: | Vox Sanguinis. 67:187-190 |
| ISSN: | 1423-0410 0042-9007 |
| Popis: | To evaluate the effectiveness of screening test for antibody to hepatitis C virus (anti-HCV), the incidence of acute post-transfusion HCV infection in patients who underwent cardiovascular surgery and received blood transfusion was studied. All patients were followed prospectively with serum biochemistry tests and viral hepatitis markers before and periodically for at least 6 months after cardiovascular surgery. None of them had history of liver disease and none tested positive for anti-HCV prior to blood transfusion. Before blood donors were screened for anti-HCV with a second-generation HCV diagnostic kit, 28 (12.4%) of 226 patients or 0.49% of 5,690 unit transfusion had seroconverted to anti-HCV during a 6-month follow-up. The incidence of post-transfusion hepatitis (PTH) C in 91 patients who had received 1-12 units transfusion was significantly lower than in 135 patients who had received more than 12 units transfusion (6.6 vs. 16.3%, p < 0.05). However, none of the 87 transfused patients, since anti-HCV screening in July 1992, developed PTH C (p < 0.05). The result demonstrates that screening for anti-HCV by a more sensitive second-generation HCV diagnostic assay may protect the patients studied from PTH C. It further provides a firm argument for the necessity of a nation-wide blood donor screening. |
| Databáze: | OpenAIRE |
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