Epithienamycins-novel .BETA.-lactams related to thienamycin I. Production and antibacterial activity
| Autor: | E O, Stapley, P J, Cassidy, J, Tunac, R L, Monaghan, M, Jackson, S, Hernandez, S B, Zimmerman, J M, Mata, S A, Currie, D, Daoust, D, Hendlin |
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| Rok vydání: | 1981 |
| Předmět: |
medicine.drug_class
Antibiotics Biology beta-Lactams Microbiology Beta-lactam Cell wall Mice chemistry.chemical_compound Species Specificity Drug Discovery medicine Animals Fermentation broth Soil Microbiology Pharmacology Bacteria Streptomyces In vitro Anti-Bacterial Agents Culture Media Thienamycin Biochemistry chemistry Fermentation Thienamycins Antibacterial activity |
| Zdroj: | The Journal of Antibiotics. 34:628-636 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.34.628 |
| Popis: | The epithienamycins are cell wall active antibiotics structurally related to N-acetylthienamycin. We have found forty-three isolated of Streptomyces flavogriseus which are capable of producing members of the epithienamycin family. Six major epithienamycin components, and xanthomycin, have been isolated from fermentation broth. Fermentation conditions can be varied to enrich for certain members of the epithienamycin family. All six components show activity in vitro versus a broad spectrum of bacterial species. The weight potencies vary 27 fold from the most active to least active. |
| Databáze: | OpenAIRE |
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