X-ray cross-complementing groups 1 rs1799782 C>T polymorphisms and colorectal cancer susceptibility: A meta-analysis based on Chinese Han population
| Autor: | Xingjie Shang, Junfeng Qian, Fang Xu, Yongwei Zhuang, Liming Wang, Chunxiao Ying |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
China medicine.medical_specialty Genotype Colorectal cancer Bioinformatics Polymorphism Single Nucleotide lcsh:RC254-282 Gastroenterology susceptibility Cohort Studies 03 medical and health sciences Asian People Internal medicine Genetic model X-ray cross-complementing groups 1 gene medicine Humans Genetic Predisposition to Disease Radiology Nuclear Medicine and imaging Alleles Models Genetic business.industry Cancer General Medicine Odds ratio Publication bias lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Confidence interval DNA-Binding Proteins meta-analysis X-ray Repair Cross Complementing Protein 1 030104 developmental biology Oncology Case-Control Studies Meta-analysis Colorectal Neoplasms polymorphisms business |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 12, Iss 8, Pp 264-267 (2016) |
| ISSN: | 0973-1482 |
| Popis: | Objective: X-ray cross-complementing groups 1 (XRCC1) rs1799782 C>T polymorphisms and colorectal cancer susceptibility were not clear. The purpose of this study was to evaluate the association between XRCC1 rs1799782 C>T polymorphisms and colorectal cancer susceptibility by meta-analysis. Materials and Methods: Related databases of Medline, CNKI, and Wanfang were systematic searched for the studies related to XRCC1 rs1799782 C>T polymorphisms and colorectal cancer risk in Chinese Han population. The genotype distribution of CC, CT and TT were extracted from each included studies in the colorectal cancer patients and healthy control subjects. The odds ratio (OR) and its 95% confidence interval (95% CI) was used to assess the correlation between genetype and colorectal cancer risk. The publications for this study was evaluated by Begg's funnel plot and Egger's line regression test. Results: The median frequency of CC, CT, and TT genotype in cancer group were 48%, 41% and 11%; For control group, they were 51%, 40% and 8%; the pooled results showed that OR = 1.32 (95% CI: 1.041–1.67, P < 0.05). The pooled results indicated that XRCC1 rs1799782 C>T polymorphisms was associated with colorectal cancer susceptibility in recessive genetic model OR = 1.32 (95% CI: 1.041–1.67, P < 0.05), dominant genetic model OR = 1.21 (95% CI: 1.00–1.46, P < 0.05) and homozygous genetic model OR = 1.43 (95% CI: 1.07–1.91, P < 0.05). The funnel plot was significant asymmetric at the bottom and the Egger's test also indicated significant publication bias (t = 2.43, P = 0.04) for recessive genetic model. But, no publication bias was found in dominant and homozygous model (P > 0.05). Conclusion: Chinese Han people with rs1799782 TT/CT genotype of XRCC1 gene may have increased risk of developing colorectal. |
| Databáze: | OpenAIRE |
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