Serum matrix metalloproteinase-1 level represents disease activity as opposed to fibrosis in patients with histologically proven nonalcoholic steatohepatitis
| Autor: | Nobuhiro Tsutsui, Yutaka Inagaki, Katsuya Otori, Yutaka Suzuki, Hiroaki Yokomori, Wataru Ando, Eigoro Yamanouchi, Isao Okazaki, Masaya Oda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Leptin
Male 0301 basic medicine Pathology Chemokine Cirrhosis Matrix metalloproteinase Severity of Illness Index Gastroenterology Monocytes 0302 clinical medicine Non-alcoholic Fatty Liver Disease Fibrosis Granulocyte Colony-Stimulating Factor Matrix metalloprotease 1 Chemokine CCL2 biology Middle Aged Ghrelin medicine.anatomical_structure 030220 oncology & carcinogenesis Hepatocellular carcinoma Cytokines Original Article Female Matrix Metalloproteinase 1 Adult medicine.medical_specialty Kupffer Cells digestive system 03 medical and health sciences Internal medicine medicine Humans Nonalcoholic steatohepatitis lcsh:RC799-869 Molecular Biology Aged Hepatology business.industry Monocyte Case-control study medicine.disease digestive system diseases 030104 developmental biology Case-Control Studies Liver cirrhosis biology.protein Hepatic stellate cell lcsh:Diseases of the digestive system. Gastroenterology business |
| Zdroj: | Clinical and Molecular Hepatology, Vol 24, Iss 1, Pp 61-76 (2018) Clinical and Molecular Hepatology |
| ISSN: | 2287-2728 |
| Popis: | Background/Aims: Nonalcoholic steatohepatitis (NASH) is prevalent in both economically developed and developing countries. Twenty percent of NASH progresses to cirrhosis with/without hepatocellular carcinoma, and there is an urgent need to find biomarkers for early diagnosis and monitoring progression of the disease. Using immunohistochemical and immunoelectron microscopic examination we previously reported that expression of matrix metalloproteinase-1 (MMP- 1) increased in monocytes, Kupffer cells and hepatic stellate cells in early stage NASH. The present study investigated whether serum MMP-1 levels reflect disease activity and pharmaceutical effects in NASH patients. Methods: We measured the serum levels of MMPs, tissue inhibitors of metalloproteinases (TIMPs), and several cytokines/ chemokines in patients with histologically proven early and advanced stages of NASH and compared them with those in healthy controls. Results: Serum MMP-1 levels in stage 1 fibrosis, but not in the more advanced fibrosis stages, were significantly higher than in healthy controls (P=0.019). There was no correlation between serum MMP-1 level and fibrosis stage. Serum MMP- 1 levels in NASH patients represented disease activity estimated by serum aminotransferase values during the followup period. In contrast, MMP-2, MMP-9 and TIMPs did not change with disease activity. Consistent with the finding that MMP-1 is expressed predominantly in monocytes and Kupffer cells, serum levels of monocyte chemotactic protein-1 and granulocyte-colony stimulating factor were significantly increased in NASH with stage 1 fibrosis. Conclusions: These results suggest that serum MMP-1 levels represent disease activity and may serve as a potential biomarker for monitoring the progression of NASH. (Clin Mol Hepatol 2018;24:61-76) |
| Databáze: | OpenAIRE |
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