Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts
| Autor: | Shimaa M. El Shafay, Eman Ahmed Bases, Rania A. El-Shenody, Mostafa M. El-Sheekh |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
antioxidant
DPPH Flavonoid Padina pavonica anticancer chemistry.chemical_compound Tannic acid T1-995 TX341-641 Food science Gallic acid Technology (General) anti-inflammatory chemistry.chemical_classification biology Nutrition. Foods and food supply secondary metabolites antidiabetic Jania rubens Haemolysis biology.organism_classification seaweeds chemistry cytotoxicity Quercetin Food Science Biotechnology |
| Zdroj: | Food Science and Technology, Issue: ahead, Published: 01 SEP 2021 Food Science and Technology, Volume: 42, Article number: e20521, Published: 01 SEP 2021 Food Science and Technology v.42 2022 Food Science and Technology (Campinas) Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) instacron:SBCTA Food Science and Technology (2021) |
| ISSN: | 1678-457X 0101-2061 |
| DOI: | 10.1590/fst.20521 |
| Popis: | This study aims to evaluate the secondary metabolites, cytotoxicity, antioxidant, antidiabetic, anti-inflammatory, and anticancer activities of four selected seaweeds Padina pavonica, Taonia atomaria, Jania rubens, and Corallina elongata. The maximum value of phenolic content (176.7 ± 6.9 mg gallic acid equivalents/g crude extract) and tannin content (26.5 ± 4.3 mg tannic acid equivalents/g crude extract), was shown in the methanol extract of J. rubens and P. pavonica, respectively. While the ethanol extract of T. atomaria recorded the highest values of total flavonoid content (374.1 ±27.4 mg quercetin equivalents/g crude extract) and total saponins content (30.2 ± 0.7 mg cholesterol equivalents/g crude extract, respectively) compared to other seaweeds. Methanol extract of J. rubens and C. elongata exhibited the greatest content of alkaloids (25.8 ± 4.4 and 22.7 ± 2.6 mg/g d wt.). The methanol extract of P. pavonica established the highest DPPH radical scavenging activity (55.7% ± 0.1) at 50 μg/mL. Among the selected seaweed extracts, the ethanol extract of T. atomaria demonstrated the maximum α-amylase inhibition capacity (66.3% ± 0.0). Methanol extract of J. rubens and P. pavonica species effectively prevented the hypotonicity-induced haemolysis in a concentration-dependent manner compared with the diclofenac potassium as a standard anti-inflammatory drug. In vitro, the reported results also supported the safety and non-toxicity of the four seaweed extracts on WI-38 cell line at lower concentrations. J. rubens and P. pavonica methanol extracts recorded the highest cell growth inhibition of the HeLa Cancer Cell Lines compared to other seaweed extracts and the standard drug Cisplatin. |
| Databáze: | OpenAIRE |
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