Omega-3 Fatty Acid Supplementation, Pro-Resolving Mediators, and Clinical Outcomes in Maternal-Infant Pairs
| Autor: | Katherine Rilett, Samuel Zoucha, Caleb Cave, Rebecca Johnson, Tara M. Nordgren, Corrine Hanson, Ann L. Anderson Berry, Sai Sujana Maddipati, Matthew Van Ormer, Elizabeth McGinn, Harriet Appeah, Kara Weishaar, Elizabeth Elliott |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Neonatal intensive care unit specialized pro-resolving lipid mediator Pregnancy High-Risk specialized pro-resolving lipid mediator (SPM) Anti-Inflammatory Agents Reproductive health and childbirth Immunologic Pregnancy Neonatal Surveys and Questionnaires Infant Mortality Medicine chemistry.chemical_classification Pediatric Omega-3 Nutrition And Dietetics Nutrition and Dietetics Fatty Acids Pregnancy Outcome omega-3 fatty acid Prenatal Care docosahexaenoic acid Fetal Blood Diet Records 3. Good health Docosahexaenoic acid Biomarker (medicine) Female pregnancy lcsh:Nutrition. Foods and food supply Adult fetal health medicine.medical_specialty Docosahexaenoic Acids lcsh:TX341-641 Article resolvins 03 medical and health sciences Food Sciences Adjuvants Immunologic Clinical Research Internal medicine Fatty Acids Omega-3 Complementary and Integrative Health Humans docosahexaenoic acid (DHA) Adjuvants Omega 3 fatty acid Nutrition 030109 nutrition & dietetics business.industry Prevention fungi Infant Newborn Intensive Care Fatty acid Infant Lipid signaling Perinatal Period - Conditions Originating in Perinatal Period medicine.disease Newborn 030104 developmental biology Endocrinology chemistry Dietary Supplements Omega 3 fatty acid supplementation Intensive Care Neonatal High-Risk business Food Science |
| Zdroj: | Nutrients, Vol 11, Iss 1, p 98 (2019) Nutrients, vol 11, iss 1 Nordgren, Tara M; Anderson Berry, Ann; Van Ormer, Matthew; Zoucha, Samuel; Elliott, Elizabeth; Johnson, Rebecca; et al.(2019). Omega-3 Fatty Acid Supplementation, Pro-Resolving Mediators, and Clinical Outcomes in Maternal-Infant Pairs.. Nutrients, 11(1), 98-98. doi: 10.3390/nu11010098. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/5970b90f Nutrients Volume 11 Issue 1 |
| ISSN: | 2072-6643 |
| Popis: | Omega (n)-3 fatty acids are vital to neonatal maturation, and recent investigations reveal n-3 fatty acids serve as substrates for the biosynthesis of specialized pro-resolving lipid mediators (SPM) that have anti-inflammatory and immune-stimulating effects. The role SPM play in the protection against negative maternal-fetal health outcomes is unclear, and there are no current biomarkers of n-3 fatty acid sufficiency. We sought to ascertain the relationships between n-3 fatty acid intake, SPM levels, and maternal-fetal health outcomes. We obtained n-3 fatty acid intake information from 136 mothers admitted for delivery using a food frequency questionnaire and measured docosahexaenoic acid (DHA)-derived SPMs resolvin D1 (RvD1) and RvD2 in maternal and cord plasma. We found significantly elevated SPM in maternal versus cord plasma, and increased SPM levels were associated with at-risk outcomes. We also identified that increased DHA intake was associated with elevated maternal plasma RvD1 (p = 0.03 R2 = 0.18) and RvD2 (p = 0.04 R2 = 0.20) in the setting of neonatal intensive care unit (NICU) admission. These findings indicate that increased n-3 fatty acid intake may provide increased substrate for the production of SPM during high-risk pregnancy/delivery conditions, and that increased maternal plasma SPM could serve as a biomarker for negative neonatal outcomes. |
| Databáze: | OpenAIRE |
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