Synthesis, characterization luminiscence studies and microbial activity of ethylenediamine ruthenium (II) complexes with dipyridophenazine ligands
| Autor: | K S Karthikeyan, J. Naveena Lavanya Latha, Penumaka Nagababu, Y. Praveen Kumar, Nazar Md Gabra, M. Rajender Reddy, Mynam Shilpa, Sirasani Satyanarayana |
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| Rok vydání: | 2010 |
| Předmět: |
Circular dichroism
Sociology and Political Science Stereochemistry Clinical Biochemistry Phenazine chemistry.chemical_element Ethylenediamine Ligands Biochemistry Medicinal chemistry Ruthenium chemistry.chemical_compound Transition metal Organometallic Compounds Spectroscopy Ligand DNA Carbon-13 NMR Ethylenediamines Anti-Bacterial Agents Clinical Psychology chemistry Luminescent Measurements Mass spectrum Phenazines Law Social Sciences (miscellaneous) DNA Damage |
| Zdroj: | Journal of fluorescence. 21(3) |
| ISSN: | 1573-4994 |
| Popis: | Three symmetric ligands 7-methyl dipyrido-[3,2-a;2',3'-c]phenazine (dppz-CH(3)), 7-nitro dipyrido-[3,2-a;2',3'-c]phenazine (dppz-NO(2)) and benzo[i]dipyrido-[3,2-a;2',3'-c]phenazine (dppn) and their ruthenium(II) complexes [Ru(en)(2)(L)][ClO(4)](2) (en= ethylenediamine), L= dppz-CH(3), dppz-NO(2) and dppn have been synthesized and characterized by IR, (1)H, (13)C NMR and Mass spectra. The interactions of these complexes with calf thymus DNA have been investigated by spectrophotometric, spectrofluorimetric, circular dichroism, viscosity and thermal denaturation studies. As the planar extension of the intercalative ligand increases, the interaction of the complex with DNA increases, indicating that the size and shape of the intercalalative ligand has a marked effect on the strength of interaction. The plot of log K versus log [Na(+)] yield a slope of -1.26, -1.53, -1.60 for the complexes 1, 2 and 3 respectively. These three complexes have been found to promote the cleavage of plasmid pBR 322 DNA upon irradiation. |
| Databáze: | OpenAIRE |
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