Procollagen-type III peptide serum concentrations in alcoholic and non-alcoholic liver disease
| Autor: | Guido Croce, Roberto Natangelo, Concetta Petrini, Silvia Perolini, Lucio Adelasco, Francesca Pozzi, Antonio Monarca |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Alcoholic liver disease Siderosis Cirrhosis Clinical Biochemistry Gastroenterology Liver disease Liver Cirrhosis Alcoholic Fibrosis Internal medicine medicine Humans Liver Diseases Alcoholic Aged Hepatitis Chronic Hepatitis business.industry Liver Diseases Fatty liver Middle Aged Hepatitis B medicine.disease Peptide Fragments Female Steatosis business Procollagen Fatty Liver Alcoholic |
| Zdroj: | La Ricerca in Clinica e in Laboratorio. 15:167-171 |
| ISSN: | 0390-5748 |
| Popis: | The type III procollagen aminopeptide (sPIIIP) serum levels were measured in 197 patients with liver disease and were correlated with morphological and serological alterations and with alcohol drinking habits. The sPIIIP levels resulted significantly increased in 51% of 43 patients with untreated chronic active hepatitis (CAH), in 61% of 36 patients with CAH plus cirrhosis, in 69% of 26 patients with inactive cirrhosis, in 4 out of 8 patients with alcoholic steatosis and fibrillogenesis, but remained unchanged in 38 cases of alcoholic steatosis plus siderosis and in 13 cases of chronic persistent hepatitis. A correlation between sPIIIP levels and the histological pattern of fibrosis could not be demonstrated in a single type of fibrotic liver disease and no differences were found between alcoholic and non-alcoholic patients. We agree upon the opinion that high sPIIIP levels may identify liver fibrogenic activity, but this test needs further technical improvements before it could be widely used in the clinical practice. |
| Databáze: | OpenAIRE |
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