The Yin and Yang of Oxidation in the Development of the Fatty Streak
| Autor: | A D Watson, Judith A. Berliner, Aldon J. Lusis, Mary C. Territo, Peter A. Edwards, B J Van Lenten, Joy S. Frank, Mohamad Navab, Diana M. Shih, A M Fogelman, Linda L. Demer, Susan Hama |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Arteriosclerosis Inflammation Oxidative phosphorylation Lipid peroxidation chemistry.chemical_compound Internal medicine medicine Animals Humans Phospholipids chemistry.chemical_classification biology Fatty streak Paraoxonase Biological activity Arteries Metabolism Lipoproteins LDL Enzyme Endocrinology chemistry Biochemistry biology.protein lipids (amino acids peptides and proteins) Lipid Peroxidation medicine.symptom Lipoproteins HDL Cardiology and Cardiovascular Medicine |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 16:831-842 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.16.7.831 |
| Popis: | Recent data support the hypothesis that the fatty streak develops in response to specific phospholipids contained in LDL that become trapped in the artery wall and become oxidized as a result of exposure to the oxidative waste of the artery wall cells. The antioxidants present within both LDL and the microenvironments in which LDL is trapped function to prevent the formation of these biologically active, oxidized lipids. Enzymes associated with LDL and HDL (eg, platelet activating factor acetylhydrolase) or with HDL alone (eg, paraoxonase) destroy these biologically active lipids. The regulation and expression of these enzymes are determined genetically and are also significantly modified by environmental influences, including the acute-phase response or an atherogenic diet. The balance of these multiple factors leads to an induction or suppression of the inflammatory response in the artery wall and determines the clinical course. |
| Databáze: | OpenAIRE |
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