Huntingtin gene intermediate alleles influence the progression from subjective cognitive decline to mild cognitive impairment: A 14-year follow-up study

Autor:	Salvatore Mazzeo, Filippo Emiliani, Silvia Bagnoli, Sonia Padiglioni, Vittoria Conti, Assunta Ingannato, Giulia Giacomucci, Juri Balestrini, Camilla Ferrari, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi
Rok vydání:	2022
Předmět:	Apolipoproteins E Neurology Alzheimer Disease Disease Progression Humans Cognitive Dysfunction Neurology (clinical) Neuropsychological Tests Alleles Follow-Up Studies
Zdroj:	European journal of neurologyREFERENCES. 29(6)
ISSN:	1468-1331
Popis:	Huntingtin (HTT) is a gene containing a key region of CAG repeats. HTT alleles containing from 27 to 35 CAG repeats are termed intermediate alleles (IAs). We aimed to assess the effect of IAs on progression of cognitive impairment in patients with subjective cognitive decline (SCD).We included 106 patients with SCD. All the patients underwent neuropsychological assessments and blood sample collection at baseline. Patients were followed up for a median (interquartile range) time of 13.75 (8.17) years. We genotyped APOE and HTT at the end of the follow-up.Eleven out of 106 patients (10.38%, 95% confidence interval [CI] 4.57-16.18) were carriers of IAs (IAIntermediate alleles interact with age and APOE ɛ4, increasing the risk of progression to MCI in SCD patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9129c22cd8c3011da70f8101881a8746 https://pubmed.ncbi.nlm.nih.gov/35181957 Zobrazit plný text záznamu Plný text