Role of VEGF, CD105, and CD31 in the Prognosis of Colorectal Cancer Cases
| Autor: | Hanaa M. Ibrahim, Mona Salah, Salem Y Mohamed, Hanan Lotfy Mohammed, Elshaimaa Mohamed Mohamed |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Oncology CD31 medicine.medical_specialty Colorectal cancer Angiogenesis medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Aged business.industry Endoglin Gastroenterology Cancer Middle Aged Prognosis medicine.disease Platelet Endothelial Cell Adhesion Molecule-1 Radiation therapy Vascular endothelial growth factor A 030220 oncology & carcinogenesis cardiovascular system Immunohistochemistry Female 030211 gastroenterology & hepatology Colorectal Neoplasms business |
| Zdroj: | Journal of Gastrointestinal Cancer. 50:23-34 |
| ISSN: | 1941-6636 1941-6628 |
| Popis: | Colorectal cancer (CRC) incidence is increasing globally. It is ranked as the second most common cancer in women and the third most in men. Angiogenesis plays a significant role in the development and spread of colorectal cancer. Angiogenesis has been proposed as a prognostic marker in a variety of human neoplasms. In this regard, markers of angiogenic endothelial cells are emerging as targets for cancer therapy. The aim of this study is to evaluate the prognostic impact of tumor angiogenesis assessed by microvessel density (MVD) counting using CD31 and CD105 along with VEGF immunostaining in colorectal cancer patients. VEGF, CD31, and CD105 expressions were evaluated using immunohistochemical staining in 50 patients with colorectal cancer. The relationship between their expressions and clinicopathological factors and outcome of patients were analyzed. The VEGF expression (70% of the cases) correlated significantly with larger tumor size, higher grade, and advanced tumor stage (p = 0.006, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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