Sensitization of A-549 lung cancer cells to Cisplatin by Quinacrine-loaded lipidic nanoparticles via suppressing Nrf2 mediated defense mechanism

Autor: Mohammadbagher Pirouzpanah, Mehdi Sabzichi, Mostafa Mohammadi, Shiva Mahmoudi, Marjan Ghorbani, Hossain Bijanpour, Jamal Mohammadian, Mohsen Rashidi, Fatemeh Ramezani, Shahram Ahmadian, Nazila Fathi Maroufi
Rok vydání: 2021
Předmět:
Zdroj: Naunyn-Schmiedeberg's Archives of Pharmacology. 394:1521-1528
ISSN: 1432-1912
0028-1298
DOI: 10.1007/s00210-021-02079-1
Popis: Nuclear factor erythroid 2-related factor 2 (Nrf2) is believed to be responsible for the control mechanisms of cellular defense response and master regulator of antioxidant system by adjustment of endogenous antioxidants, phase II detoxifying enzymes and transporters, so inhibition of Nrf2 could be considered molecule target to overcome drug resistance and cancer progression. By harnessing liposome as an advanced nanoparticles transporter, we formulated Quinacrine known as nrf2 inhibitor into nano-carrier, and sensitized A-549 lung tumor cells to Cisplatin. The aim of this work was to prepare liposome nano-carriers to enhance the bioavailability of Quinacrine and to improve passive targeting in A549 cells. Quinacrine formulation into liposome exposed a mean particle size of 80±5 nm in passive targeting and 110±3 after decoration with chitosan oligosaccharides (COS), respectively. The highest amount of cell death (p
Databáze: OpenAIRE
Externí odkaz: