Effect of Cytokines on the Formation Tube-Like Structures by Endothelial Cells in the Presence of Trophoblast Cells
| Autor: | S. A. Selkov, K. L. Belyakova, T. Yu. L’vova, D. I. Sokolov, V. A. Mikhailova, A. R. Sheveleva, O. I. Stepanova, L. S. Okorokova |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Endothelium Angiogenesis Placenta General Biochemistry Genetics and Molecular Biology Cell Line 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans reproductive and urinary physiology 030219 obstetrics & reproductive medicine Interleukin-6 Tumor Necrosis Factor-alpha Chemistry Interleukin-8 Endothelial Cells Trophoblast General Medicine Interleukin-10 Trophoblasts Cell biology 030104 developmental biology medicine.anatomical_structure embryonic structures Cytokines Female Cytokine secretion |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 163:148-158 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-017-3756-4 |
| Popis: | Despite ample data on cytokine secretion in the uteroplacental interface, the influence of microenvironment cells, in particular, trophoblast cells on angiogenesis and the role of cytokines in this process remain poorly studied. We studied the influence of cytokines on the formation of tube-like structures by endothelial cells in the presence of trophoblast cells and showed that trophoblast cells suppressed the angiogenic potential of endothelial cells. Antiangiogenic cytokines IFN-γ, IL-10, TNF-α, and TGFβ via modulation of trophoblast cells stimulated the formation of tube-like structures by endothelial cells. In the co-culture of endothelial and trophoblast cells, the effects of cytokines changed and they gained additional regulatory functions. |
| Databáze: | OpenAIRE |
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