Extent of prostate-specific antigen contamination in the Spanish section of the European Randomized Study of Screening for Prostate Cancer (ERSPC)
| Autor: | Carlos Pascual, Javier C. Angulo, Elena Miravalles, Alvaro Paez, Marcos Lujan, A. Berenguer |
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| Rok vydání: | 2006 |
| Předmět: |
Oncology
Male medicine.medical_specialty Randomization Time Factors Urology Biopsy law.invention Prostate cancer Randomized controlled trial Prostate law Internal medicine medicine Biomarkers Tumor Humans Mass Screening Mass screening Aged Neoplasm Staging Gynecology medicine.diagnostic_test business.industry Incidence Prostatic Neoplasms Middle Aged Prostate-Specific Antigen medicine.disease Prognosis Prostate-specific antigen medicine.anatomical_structure Prostate cancer screening Spain business |
| Zdroj: | European urology. 50(6) |
| ISSN: | 0302-2838 |
| Popis: | The performance of tests outside prostate cancer screening trials (PSA contamination) may affect their statistical power. The present study addressed the extent of PSA contamination in the Spanish section of the European Randomized Study of Screening for Prostate Cancer (ERSPC) and its impact on biopsy performance and prostate cancer detection.Data linkage was performed to address screening-related interventions outside the study. Four databases were used: (1) Spanish ERSPC database (n=4278), (2) laboratory database with all PSA determinations (n=31,140), (3) database of 1608 prostate biopsies, and (4) records of all prostate cancers (n=819) diagnosed at our centre. PSA contamination, biopsy performance, and cancer detection rates were calculated.Median follow-up time was 6.6 yr. A total of 2201 PSA determinations were performed for 1253 men. Cumulative PSA contamination was 29.3% (17% in the control arm during the first 4 yr). A higher proportion of men undergoing biopsies was found in the screening arm (21.3% vs. 2.9% in the control arm, p0.0001). Similarly, higher cancer detection rates were found in the screening (4.7% vs. 1.2% in the control arm, p0.0001).In our experience, the PSA contamination rate has increased during the last years, but its impact on biopsy performance and cancer detection in the control arm of the trial is limited and not likely to compromise the statistical power of the ERSPC trial. |
| Databáze: | OpenAIRE |
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