A Crosstalk on Codon Usage in Genes Associated with Leukemia
| Autor: | Yashmin Choudhury, Supriyo Chakraborty, S. B. Paul, Yeongseon Ahn, Yoon Shin Cho, Arif Uddin, Durbba Nath |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Protein Folding DNA Mutational Analysis Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Genetics medicine Humans Genetic Predisposition to Disease RNA Messenger Selection Genetic Codon Codon Usage Molecular Biology Mutational pressure Gene Ecology Evolution Behavior and Systematics Leukemia Natural selection Nucleotides fungi Computational Biology General Medicine medicine.disease Human genetics Crosstalk (biology) 030104 developmental biology 030220 oncology & carcinogenesis Codon usage bias Mutation Genes Neoplasm |
| Zdroj: | Biochemical Genetics. 59:235-255 |
| ISSN: | 1573-4927 0006-2928 |
| Popis: | Leukemia is the outcome of aggregation of damaged white blood cells. Several genes were reported to be associated with the pathogenesis of leukemia. These genes were computationally analyzed to decipher their codon usage bias (CUB) and to identify the prime factors influencing the codon usage profile as no work was reported yet. The mean values of synonymous codon usage order (SCUO) parameter indicated low CUB of the genes. Significant positive association of SCUO with overall GC and positional GCs might signal the presence of mutational pressure. However, neutrality plot suggested the dominant role of natural selection across the genes. Along with natural selection, the role of mutation pressure was also prominent and that might be responsible for lower CUB (SCUO = 0.19) of genes. Low translational speed might permit accuracy in the process. A strong inverse relationship of translational rate was observed with CUB of genes and folding energy. |
| Databáze: | OpenAIRE |
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