To Include or Occlude: Rational Engineering of HCV Vaccines for Humoral Immunity
| Autor: | Heidi E. Drummer, Felicia Schlotthauer, Joey McGregor |
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| Rok vydání: | 2021 |
| Předmět: |
Models
Molecular Viral Hepatitis Vaccines 0301 basic medicine medicine.drug_class T cell Rational engineering Bioengineering Review Hepacivirus Monoclonal antibody Microbiology World health Epitopes Structure-Activity Relationship 03 medical and health sciences 0302 clinical medicine Viral Envelope Proteins humoral immunity Virology T cell immunity Humans Medicine Antigens Viral chemistry.chemical_classification business.industry Research Hepatitis C Hepatitis C Antibodies medicine.disease Antibodies Neutralizing QR1-502 Immunity Humoral Vaccinology 030104 developmental biology Infectious Diseases medicine.anatomical_structure vaccine development chemistry glycoprotein E2 Host-Pathogen Interactions Humoral immunity 030211 gastroenterology & hepatology business Glycoprotein |
| Zdroj: | Viruses Viruses, Vol 13, Iss 805, p 805 (2021) |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13050805 |
| Popis: | Direct-acting antiviral agents have proven highly effective at treating existing hepatitis C infections but despite their availability most countries will not reach the World Health Organization targets for elimination of HCV by 2030. A prophylactic vaccine remains a high priority. Whilst early vaccines focused largely on generating T cell immunity, attention is now aimed at vaccines that generate humoral immunity, either alone or in combination with T cell-based vaccines. High-resolution structures of hepatitis C viral glycoproteins and their interaction with monoclonal antibodies isolated from both cleared and chronically infected people, together with advances in vaccine technologies, provide new avenues for vaccine development. |
| Databáze: | OpenAIRE |
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