Evidence against linkage of schizophrenia to chromosome 5q11-q13 markers in systematically ascertained families
| Autor: | D.B. Wildenauer, Martha A. Ertl, Joachim Hallmayer, Jtirgen Minges, Sabine Schmidt, Wolfgang Maier, Manfred Ackenheil, Dirk Lichtermann |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Linkage (software)
Genetics Genetic Markers congenital hereditary and neonatal diseases and abnormalities Genetic Linkage Research Diagnostic Criteria Pedigree chart medicine.disease Family member Chromosome (genetic algorithm) Psychotic Disorders Schizophrenia medicine Chromosomes Human Pair 5 Humans Family Lymphocytes Lod Score Psychology Biological Psychiatry Lod scores Lod score |
| Zdroj: | Biological psychiatry. 31(1) |
| ISSN: | 0006-3223 |
| Popis: | Ten pedigrees systematically ascertained in Germany were tested for linkage to chromosome 5q11-q13. In order to replicate the previous report by Sherrington et al (1988), families with a bipolar family member were omitted from the lod score calculations, all diagnoses were based upon Research Diagnostic Criteria, and four different models of the affection status were calculated, including the model for which Sherrington et al calculated the highest lod scores. None of the families investigated showed a positive lod score. Using multipoint linkage analyses, we were able to exclude the region for which a positive linkage has been reported. |
| Databáze: | OpenAIRE |
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