Failure of a Prospective Trial to Detect Cytomegalovirus Retinitis after Initiation of Highly Active Antiretroviral Therapy
| Autor: | Bradley S. Bender, M. Fran Smith, Constance R. Uphold |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male medicine.medical_specialty Anti-HIV Agents Opportunistic infection Congenital cytomegalovirus infection Retinitis Acquired immunodeficiency syndrome (AIDS) Surveys and Questionnaires Internal medicine medicine Humans Prospective Studies Prospective cohort study Acquired Immunodeficiency Syndrome Amsler grid AIDS-Related Opportunistic Infections business.industry Incidence Public Health Environmental and Occupational Health virus diseases Middle Aged medicine.disease Infectious Diseases Cytomegalovirus Retinitis Immunology Female Cytomegalovirus retinitis business Viral load |
| Zdroj: | AIDS Patient Care and STDs. 12:907-912 |
| ISSN: | 1557-7449 1087-2914 |
| DOI: | 10.1089/apc.1998.12.907 |
| Popis: | Thirty-one patients with AIDS with CD4+ T-cell counts of less than 75/mm3 were enrolled in a prospective study to determine the incidence of cytomegalovirus (CMV) retinitis and changes in CD4+ T-cell counts and viral loads following initiation of highly active anti-retroviral therapy (HAART). Patients were assessed using an Amsler grid, a visual field test, a questionnaire, and direct and indirect funduscopy. Only one patient developed an opportunistic infection, and the majority of patients had a threefold decrease in their viral loads and an increase in CD4+ T-cell counts within 2 months of initiating HAART. These findings support the belief that recent therapies modify the natural history of HIV infection and that new clinical approaches will be needed to address the changing profile of HIV/AIDS patients. None of our patients developed CMV retinitis. The findings add to those of other researchers, and suggest that if CMV retinitis does develop after HAART, it is an unusual finding that may be due to preexisting, subclinical retinitis rather than failure of HAART to reconstitute full immune cell recovery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|