Black seed oil ameliorated scopolamine-induced memory dysfunction and cortico-hippocampal neural alterations in male Wistar rats
Autor: | A.Z. Lawal, AO Oyewopo, Moyosore Salihu Ajao, Aminu Imam, Musa Iyiola Ajibola, Oluwole B. Akinola, M. Y. Adana, Abdulbasit Amin, Abdul-Musawwir Alli-Oluwafuyi, Olayemi Joseph Olajide, Wahab Imam Abdulmajeed |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Memory Dysfunction Scopolamine lcsh:RS1-441 Amnesia Morris water navigation task Hippocampal formation lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Cognitive dysfunction Oral administration Ameliorative efficacy Internal medicine medicine Dementia Memory impairment Cortico-hippocampal neurons Black seed oil business.industry medicine.disease 030104 developmental biology Endocrinology Anesthesia Latency stage medicine.symptom business 030217 neurology & neurosurgery |
Zdroj: | Bulletin of Faculty of Pharmacy, Cairo University, Vol 54, Iss 1, Pp 49-57 (2016) |
ISSN: | 1110-0931 |
Popis: | This study was conducted to evaluate cognitive enhancing effect and ameliorative effects of black seed oil in scopolamine induced rat model of cognitive impairment. These effects were investigated on scopolamine-induced dementia model in Morris water maze test (MWM) and Y maze test. The hippocampal histoarchitectural responses to scopolamine and Nigella sativa oil were also examined. Scopolamine (1 mg/kg ip) was given to induce dementia, followed by oral administration of BSO (1 ml/kg) for 14 consecutive days. MWM and Y-maze paradigms were used to assess hippocampal and frontal dependent memory respectively, thereafter the rats were sacrificed and brains were removed for histopathologic studies. Scopolamine resulted in memory impairment, by delayed latency in the MWM, reduced percentage alternation in the Y maze that was coupled by alterations in the cortico-hippocampal neurons. Posttreatment of rats with BSO mitigated scopolamine-induced amnesia, by reducing latency period and increasing percentage alternation and histological changes. The observed anti-amnestic effect of BSO makes it a promising anti-amnesic agent for clinical trials in patients with cognitive impairment. |
Databáze: | OpenAIRE |
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