An Iron-Based Cytosolic Catalase and Superoxide Dismutase Mimic Complex
| Autor: | Jullyane A. S. Santos, Manfredo Hörner, Gabrieli L. Parrilha, Monique S. Santos, Elis C. A. Eleutherio, Adolfo Horn, Lorenzo do Canto Visentin, Karen V. Melo, Christiane Fernandes, Marcos D. Pereira |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Saccharomyces cerevisiae Proteins
Antioxidant Iron medicine.medical_treatment SOD1 Saccharomyces cerevisiae Ligands Antioxidants Inorganic Chemistry Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Cytosol medicine Physical and Theoretical Chemistry Hydrogen peroxide Molecular Structure biology Superoxide Dismutase Chemistry Superoxide Hydrogen Peroxide Catalase Oxidative Stress Biochemistry Tripodal ligand biology.protein Reactive Oxygen Species Protein Binding |
| Zdroj: | Inorganic Chemistry. 49:1274-1276 |
| ISSN: | 1520-510X 0020-1669 |
| Popis: | The development of metallodrugs with antioxidant activities is of importance as a way to protect organisms exposed to stressful conditions. Although iron chemistry in the presence of H(2)O(2) is usually associated with pro-oxidant activity, mainly via the Fenton reaction, we found that the mononuclear compound [Fe(HPClNOL)Cl(2)]NO(3) (1; C(15)H(18)Cl(3)FeN(4)O(4), a = 8.7751(3) A, b = 9.0778(4) A, c = 24.3869(10) A, beta = 93.370(2) degrees , monoclinic, P2(1)/c, Z = 4), containing the tripodal ligand 1-[bis(pyridin-2-ylmethyl)amino]-3-chloropropan-2-ol, decomposes hydrogen peroxide and superoxide anion in vitro as well as shows in vivo protection because it prevents the harmful effects promoted by H(2)O(2) on Saccharomyces cerevisiae cells, decreasing the level of lipid peroxidation. This protective effect was observed for wild-type cells, as well as for mutant cells, which do not present the antioxidant metalloenzymes catalase (Ctt1) or copper/zinc superoxide dismutase (Sod1). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|