Does intensity-modulated radiation therapy (IMRT) alter prostate size? Magnetic resonance imaging evaluation of patients undergoing IMRT alone
| Autor: | Takahiro Yamaguchi, Masayuki Matsuo, Shingo Kamei, Masahide Hayashi, Hidekazu Tanaka, Kae Hachiya, Hironori Nishibori, Satoshi Ishihara, Shinichi Ogawa |
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| Rok vydání: | 2017 |
| Předmět: |
Entire prostate
medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Original research article Magnetic resonance imaging Intensity-modulated radiation therapy medicine.disease Prostate size 030218 nuclear medicine & medical imaging Radiation therapy stomatognathic diseases 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine.anatomical_structure Oncology Prostate 030220 oncology & carcinogenesis Medicine Radiology Nuclear Medicine and imaging In patient Radiology business |
| Zdroj: | Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology. 22(6) |
| ISSN: | 1507-1367 |
| Popis: | Aim To assess the changes in prostate size in patients with prostate cancer undergoing intensity-modulated radiation therapy (IMRT). Background The effect of size change produced by IMRT is not well known. Materials and methods We enrolled 72 patients who received IMRT alone without androgen-deprivation therapy and underwent magnetic resonance imaging (MRI) examination before and after IMRT. The diameter of the entire prostate in the anterior–posterior (P-AP) and left–right (P-LR) directions was measured. The transitional zone diameter in the anterior–posterior (T-AP) and left–right (T-LR) directions was also measured. Results The average relative P-AP values at 3, 6, 12, 24, and 36 months after IMRT compared to the pre-IMRT value were 0.94, 0.90, 0.89, 0.89, and 0.90, respectively; the average relative P-LR values were 0.93, 0.92, 0.91, 0.91, and 0.90, respectively. The average P-AP and P-LR decreased by approximately 10% during the 12 months post-IMRT, and remained unchanged thereafter. The average relative T-AP values at 3, 6, 12, 24, and 36 months after IMRT compared to the pre-IMRT value were 0.93, 0.88, 0.91, 0.87, and 0.89, respectively; the average relative T-LR values were 0.96, 0.90, 0.91, 0.87, and 0.88, respectively. The average T-AP and T-LR also decreased by approximately 10% during the 12 months post-IMRT, and remained unchanged thereafter. At 12 months after IMRT, the average relative T-AP was significantly lower in patients with recurrence than in those without recurrence. Conclusions The average prostate diameter decreased by approximately 10% during the 12 months after IMRT; thereafter remained unchanged. |
| Databáze: | OpenAIRE |
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