MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor
| Autor: | Qifeng Luo, Yunhe Yu, Kaiyao Hua, Xuehui Wang, Changle Ji, Danrong Ye, Xiqian Zhou, Amik Munankarmy, Diya Liu, Xiaochong Deng, Lin Fang, Hongming Song, Baian Zhou, Wenfang Zheng |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Immunology Down-Regulation Breast Neoplasms Biology Protein Serine-Threonine Kinases Models Biological Article law.invention Transcriptome Cellular and Molecular Neuroscience Breast cancer law Cell Movement Cell Line Tumor medicine Humans Cell Proliferation YAP1 QH573-671 Base Sequence Protein Stability Tumor Suppressor Proteins Cell Biology medicine.disease Long non-coding RNA Gene Expression Regulation Neoplastic MicroRNAs Cytoplasm Gain of Function Mutation Mutation Cancer research Long non-coding RNAs Disease Progression Suppressor Phosphorylation Female Cytology Function (biology) |
| Zdroj: | Cell Death & Disease Cell Death and Disease, Vol 12, Iss 9, Pp 1-10 (2021) |
| ISSN: | 2041-4889 |
| Popis: | The long noncoding RNA called MIR22 host gene (MIR22HG) was previously identified as a tumor suppressor in several cancers. However, the biological function of MIR22HG in breast cancer remains unknown. In this study, we aimed to determine the function and molecular mechanism of MIR22HG in breast cancer progression using transcriptomics and biotechnological techniques. Our results showed that MIR22HG expression was lower in the cancerous tissues than in the paired adjacent normal breast tissues. Additionally, MIR22HG was found to be mainly located in the cytoplasm and acted as a miR-629-5p sponge. Notably, MIR22HG stabilized the expression of large tumor suppressor 2 (LATS2), which promoted the LATS2-dependent phosphorylation of YAP1 and suppressed the expression of its downstream target oncogenes, thereby inhibiting the proliferation and migration of breast cancer cells. Therefore, our findings reveal the MIR22HG-dependent inhibition of breast cancer cell proliferation and migration via the miR-629-5p/LATS2 pathway, providing new insights and identifying novel therapeutic targets for breast cancer treatment. |
| Databáze: | OpenAIRE |
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