White matter abnormalities in patients with temporal lobe epilepsy and amygdala enlargement: Comparison with hippocampal sclerosis and healthy subjects
| Autor: | Noriko Sato, Daichi Sone, Masako Watanabe, Etsuko Imabayashi, Kaoru Sumida, Miho Ota, Kota Yokoyama, Hiroshi Matsuda, Mitsutoshi Okazaki, Yukio Kimura, Norihide Maikusa, Yutaka Watanabe |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Corpus callosum behavioral disciplines and activities Hippocampus Functional Laterality 030218 nuclear medicine & medical imaging Temporal lobe White matter 03 medical and health sciences 0302 clinical medicine Fractional anisotropy medicine Image Processing Computer-Assisted Cingulum (brain) Humans Gray Matter Hippocampal sclerosis Sclerosis Voxel-based morphometry Organ Size Middle Aged medicine.disease Amygdala Magnetic Resonance Imaging White Matter nervous system diseases medicine.anatomical_structure Diffusion Tensor Imaging nervous system Neurology Epilepsy Temporal Lobe FMRIB Software Library Female Neurology (clinical) Psychology Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Epilepsy research. 127 |
| ISSN: | 1872-6844 |
| Popis: | Purpose Cases of temporal lobe epilepsy (TLE) with ipsilateral amygdala enlargement (AE) have increasingly been reported. However, the white matter (WM) abnormalities of TLE patients with AE remain poorly investigated. Here we explored macrostructural and microstructural WM abnormalities in TLE patients with AE compared to normal controls and TLE patients with hippocampal sclerosis (HS). Material and methods We selected 17 patients with unilateral TLE with AE (TLE-AE) based on automated amygdala volumetry using FreeSurfer software, and 34 healthy controls and 35 patients with unilateral TLE with HS (TLE-HS) were also recruited. Subsequently, differences in gray matter (GM) and WM volumes and fractional anisotropy (FA) among the three groups were analyzed using SPM8 software. Results The volume analysis of GM obtained results that are consistent with the structural characteristics of TLE with AE and with HS (i.e. amygdala increase in the TLE-AE, and mesial temporal atrophy in the TLE-HS). In the volume of WM, only the TLE-HS patients had WM reductions mainly in the ipsilateral temporal lobe. Compared to the controls, the TLE-AE group showed a significant FA decrease in the ipsilateral anterior cingulum and the corpus callosum, whereas an extended FA decrease in the whole cerebrum was observed in the TLE-HS group. Conclusion Our findings regarding the WM of TLE patients with AE may reflect characteristic pathophysiology such as the anatomical and functional connection between the amygdala and medial prefrontal cortex, and our results may thus provide insights into TLE with AE. |
| Databáze: | OpenAIRE |
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