Oxaliplatin-associated sarcoid-like reaction masquerading as recurrent colon cancer

Autor: Anup Kasi, Anusha Chidharla, Surya Aedma, Sarah Kelting
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Sarcoidosis
Colorectal cancer
medicine.medical_treatment
Adenocarcinoma
Circulating Tumor DNA
Diagnosis
Differential
03 medical and health sciences
0302 clinical medicine
Carcinoembryonic antigen
Positron Emission Tomography Computed Tomography
Antineoplastic Combined Chemotherapy Protocols
medicine
Hepatectomy
Humans
Cholecystectomy
Liquid biopsy
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Colectomy
Chemotherapy
Granuloma
medicine.diagnostic_test
biology
business.industry
Cancer
General Medicine
Perioperative
Middle Aged
medicine.disease
Oxaliplatin
Carcinoembryonic Antigen
Fine-needle aspiration
030228 respiratory system
Liver
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Colonic Neoplasms
biology.protein
Radiology
Lymph Nodes
Neoplasm Recurrence
Local
business
Spleen
medicine.drug
Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect
Zdroj: BMJ Case Rep
Popis: A 54-year-old man with stage IV B metastatic colorectal cancer with liver and peritoneal metastasis was treated with cytoreductive surgery (extended left colectomy, right partial hepatectomy, resection of right diaphragm nodule) and perioperative oxaliplatin-based chemotherapy. The patient was cancer-free for 6 months, at which point a surveillance positron emission tomography-CT scan showed metabolically active hepatosplenic lesions and mediastinal and bilateral hilar lymph nodes. An endobronchial ultrasound bronchoscopy-guided fine needle aspiration of the mediastinal and hilar lymph nodes revealed non-necrotising granulomas. The workup was negative for bacterial, fungal or mycobacterial infection, cancer or autoimmune disease. Carcinoembryonic antigen and COLVERA (a circulating tumour DNA liquid biopsy test for the detection of recurrent colon cancer) tests were negative. Subsequently the rare diagnosis of a sarcoidosis-like reaction from oxaliplatin-based chemotherapy was made. Repeat imaging after 3 months showed resolution of the hepatosplenic lesions and lymphadenopathy, alike.
Databáze: OpenAIRE
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