Pharmacokinetics and tissue localization of doxycycline polyphosphate and doxycycline hydrochloride in the rat
| Autor: | G. Michel, J. Olle, J. Mosser |
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| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Clinical chemistry Antibiotics Biology Blood–brain barrier Caecum Pharmacokinetics Internal medicine medicine Animals Tissue Distribution Pharmacology (medical) Pharmacology Doxycycline Lung Rats Inbred Strains Metabolism biology.organism_classification Rats Kinetics Endocrinology medicine.anatomical_structure Female medicine.drug |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 9:149-153 |
| ISSN: | 2107-0180 0378-7966 |
| Popis: | Two doxycycline derivatives Doxycycline polyphosphate and Doxycycline hydrochloride were administered to rats at a dose of 20 mg/kg body weight. Doxycycline tissue levels were determined using a microbiological assay. Only an insignificant fraction of the antibiotics was found to cross the blood brain barrier. Doxycycline was highly concentrated in excretory organs: liver, kidneys and caecum. The high intestinal drug level observed is probably related to the entero-hepatic cycle of this antibiotic. There was a good correlation between serum and heart doxycycline concentration; heart level was about twice that of serum. In lung, antibiotic level was always higher than in serum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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