Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica
| Autor: | M Suffness, David S. Reiner, Frances D. Gillin |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Microgram
Drug Evaluation Preclinical Drug Resistance Glaucarubin Bruceantin Drug resistance Pharmacology Entamoeba histolytica Structure-Activity Relationship parasitic diseases medicine Animals Pharmacology (medical) Amebicides Medicinal plants IC50 Plants Medicinal biology Quassins Plant Extracts Dysentery Phenanthrenes medicine.disease biology.organism_classification Infectious Diseases Quassinoid Research Article |
| Zdroj: | Antimicrobial agents and chemotherapy. 22(2) |
| ISSN: | 0066-4804 |
| Popis: | Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoids of 17 tested were also amoebicidal. No relationship between quassinoid structure and amoebicidal activity was apparent. |
| Databáze: | OpenAIRE |
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