Reperfusion-induced temporary appearance of therapeutic window in penumbra after 2 h of photothrombotic middle cerebral artery occlusion in rats
| Autor: | Toshiaki Akira, Tatsuo Nakahara, Narihiko Yoshii, Hiroshi Yao |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Time Factors Ischemia Infarction Brain Edema Neuroprotection Central nervous system disease Electrolytes medicine.artery Rats Inbred SHR Occlusion medicine Animals Fluorescent Dyes Cerebral Cortex Rose Bengal business.industry Penumbra Lasers Microfilament Proteins Infarction Middle Cerebral Artery medicine.disease Rats Disease Models Animal Neuroprotective Agents Neurology Anesthesia Cerebrovascular Circulation Middle cerebral artery Reperfusion Neurology (clinical) Laser Therapy Cardiology and Cardiovascular Medicine business Carrier Proteins Reperfusion injury Blood Flow Velocity |
| Zdroj: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 29(3) |
| ISSN: | 1559-7016 |
| Popis: | To explore the effects of reperfusion on evolution of focal ischemic injury, spontaneously hypertensive male rats were subjected to photothrombotic distal middle cerebral artery occlusion (MCAO) with or without YAG laser-induced reperfusion. The volume of fodrin breakdown zone, water content, and brain tissue levels of sodium (Na+) and potassium (K+) were measured in the ischemic core and penumbra. Reperfusion attenuated fodrin breakdown, and the volume containing fodrin breakdown product at 3 h after reperfusion (5 h after MCAO) (30±7 mm3) was significantly smaller than the 42±3 mm3 of the permanent occlusion group. After 3 to 6 h of ischemia, Na+ increased, and K+ decreased in the ischemic core. Reperfusion after 2 h of MCA occlusion did not mitigate the ischemia-induced changes in brain tissue electrolytes and water content at 3 to 6 h of ischemia. Even in reperfusion after comparatively long periods of occlusion where brain infarction size, assessed 3 days after MCAO, was not significantly reduced by reperfusion, and the precipitating indicators of the ischemic core (Na+, K+, water content) did not improve, temporary improvement or a delay in progression of ischemic injury was discernible in the penumbra. These results indicate the possibility that treatment with reperfusion is permissive to the effects of neuroprotection. |
| Databáze: | OpenAIRE |
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