Immune System Reaction against Environmental Pollutants
| Autor: | Tsuyoshi Tanabe, Masayuki Okuda, Hidekazu Takahashi, Yasutaka Ishimaru, Natsu Yamaguchi |
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| Rok vydání: | 2015 |
| Předmět: |
Inflammasomes
Receptors Cytoplasmic and Nuclear Inflammation Nod Adaptive Immunity Immune system Immunity medicine Humans Adaptor Proteins Signal Transducing Innate immune system Chemistry Pathogen-Associated Molecular Pattern Molecules Toll-Like Receptors Asbestos Inflammasome General Medicine biochemical phenomena metabolism and nutrition Silicon Dioxide Acquired immune system Immunity Innate Immune System Immunology Environmental Pollutants medicine.symptom Crystallization Inflammasome complex medicine.drug |
| Zdroj: | Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene). 70:115-119 |
| ISSN: | 1882-6482 0021-5082 |
| Popis: | Environmental pollutants (such as diesel exhaust particles and silica) cause disorders ranging from bronchial asthma to malignant tumors. In recent years, it has been reported that some of the signaling pathways in which environmental contaminants act in vivo are associated with innate immunity. Innate immunity recognizes ligands and induces inflammation. Those ligands are pathogen-associated molecular patterns (PAMPs: e.g., lipopolysaccharide) and danger-associated molecular patterns (DAMPs: e.g., cholesterol crystallization or uric acid crystal). Activation of innate immunity stimulates the acquired immunity system. Therefore, innate immunity regulates the strength of the general immune system. Furthermore, crystal silica, which is an environmental pollutant, activates innate immunity as a ligand. Innate immunity involves the membrane-bound Toll-like receptors (TLR) and cytoplasm-localized nucleotide-binding oligomerization domain (NOD)-like receptors (NLR). We reported the innate immunity-system-related diseases such as Crohn's disease, Blau syndrome, myelogenous leukemia, and sarcoidosis. An inflammasome complex containing NLR has attracted attention owing to its correlation with the onset of several diseases. It is reported that the inflammasome activation is related to the development of lifestyle-related diseases such as myocardial infarction and fatty liver. It is also reported that the mechanism by which crystal silica and asbestos cause inflammation involves the inflammasome activation. Analyzing the genes of innate immunity contributes to the clarification of the mechanism of disease onset caused by environmental pollutants. |
| Databáze: | OpenAIRE |
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