c-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer

Autor:	C. M. Schlotter, B Falkiewicz, U. Bosse, Krzysztof P. Bielawski, U. Vogt
Rok vydání:	2000
Předmět:	Oncogene business.industry CA 15-3 Cancer medicine.disease Gene dosage General Biochemistry Genetics and Molecular Biology Breast cancer medicine Cancer research Viability assay business Chemosensitivity assay Ex vivo
Zdroj:	Scopus-Elsevier
ISSN:	1734-154X 0001-527X
DOI:	10.18388/abp.2000_4072
Popis:	A pilot study on relationships of selected molecular factors (c-myc oncogene average gene copy numbers (AGCN); serum CEA and CA 15.3 antigen levels; tumor cells' DNA values), to the ex vivo chemosensitivity of primary female human breast cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Four drug combinations were tested. A group of 75 cases of female primary breast cancer was assessed. Numerous correlations were found among molecular factors tested but none, with the exception of tumor grading, of these reflected ex vivo chemosensitivity of tumors tested. The results suggest that the parameters tested may not be important factors related to adjuvant chemoresponsiveness of primary human breast cancer to tested drug combinations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910c6d16718c5539382145a97c84bbc2 https://doi.org/10.18388/abp.2000_4072 Zobrazit plný text záznamu